Hypothyroidism and the increased risk of preeclampsia - interpretative factors?

Aino Lintula; Leea Keski-Nisula; Heidi Sahlman

doi:10.1080/10641955.2020.1800030

Hypothyroidism and the increased risk of preeclampsia - interpretative factors?

Hypertens Pregnancy. 2020 Nov;39(4):411-417. doi: 10.1080/10641955.2020.1800030. Epub 2020 Aug 13.

Authors

Aino Lintula¹, Leea Keski-Nisula^{1

2}, Heidi Sahlman³

Affiliations

¹ Institute of Clinical Medicine, School of Medicine, University of Eastern Finland , Kuopio, Finland.
² Department of Obstetrics and Gynecology, Kuopio University Hospital , Kuopio, Finland.
³ School of Pharmacy, University of Eastern Finland , Kuopio, Finland.

PMID: 32787605
DOI: 10.1080/10641955.2020.1800030

Abstract

Objective: To evaluate the causes behind the association between hypothyroidism and the risk of preeclampsia.

Methods: Checking of individual hospital and birth records from 149 levothyroxine users among 2,508 women in the preeclampsia case-control study (2002-2016).

Results: There were significant association between levothyroxine medication and preeclampsia (OR 1.48, 95^th CI 1.06-2.07; p ≤ 0.022). The presence of comorbid diseases was associated with a significantly higher risk for the development of preeclampsia in women using levothyroxine.

Conclusion: Levothyroxine use during pregnancy was associated with 1.5-times higher risk for preeclampsia, but it is also linked to the other comorbid risk factors.

Keywords: Pregnancy; diabetes; hypertension; hypothyroidism; levothyroxine; preeclampsia.

MeSH terms

Adult
Case-Control Studies
Female
Humans
Hypothyroidism / complications*
Hypothyroidism / drug therapy
Pre-Eclampsia / etiology*
Pregnancy
Risk Factors
Thyroxine / adverse effects
Thyroxine / therapeutic use*
Young Adult

Substances

Thyroxine