Gene expression analysis of primary gingival cancer by whole exome sequencing in thirteen Chinese patients

Guo-Min Liu; Tian-Cheng Lu; Yun Liu; Yun-Gang Luo

Gene expression analysis of primary gingival cancer by whole exome sequencing in thirteen Chinese patients

Int J Clin Exp Pathol. 2020 Jul 1;13(7):1909-1914. eCollection 2020.

Authors

Guo-Min Liu^{1

2}, Tian-Cheng Lu^{3

2}, Yun Liu^{1

2}, Yun-Gang Luo^{4

2}

Affiliations

¹ Department of Orthopedics, The Second Hospital of Jilin University Changchun 130041, Jilin, China.
² Jilin Provincial Changbai Mountain Anti-tumor Medicine Engineering Center Changchun, Jilin, China.
³ Life Sciences College, Jilin Agricultural University Changchun 130118, Jilin, China.
⁴ Department of Stomatology, The Second Hospital of Jilin University Changchun 130041, Jilin, China.

PMID: 32782722
PMCID: PMC7414513

Abstract

Objectives: Early diagnosis of and markers for gingival oral squamous cell carcinoma (OSCC) is important for effective treatment.

Methods: The current study performed a whole exome sequencing of gingival OSCC tissues in thirteen Chinese patients to explore exonic mutants.

Results: Eighty-five genes emerged as mutants in patients with primary gingival OSCC. CCL4L1 presented a G>A transversion at chr17 17q12, position 36212480, exon 3. KDM5B presented a T>TA insertion at chr1 1q32.1, position 202766506, exon 6. ANKRD36C presented a C>G transition at chr2 2q11.1, position 95945175, exon 18.

Conclusion: These three mutants might be new markers of gingival OSCC. The finding may provide new targets to diagnose and treat gingival OSCC.

Keywords: ANKRD36C; CCL4L1; KDM5B; Whole exome sequencing; gingival cancer.