Neutrophil DNA Webs Untangled

Simon Milette; Daniela F Quail; Jonathan D Spicer

doi:10.1016/j.ccell.2020.07.002

Neutrophil DNA Webs Untangled

Cancer Cell. 2020 Aug 10;38(2):164-166. doi: 10.1016/j.ccell.2020.07.002.

Authors

Simon Milette¹, Daniela F Quail², Jonathan D Spicer³

Affiliations

¹ Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Canada; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Canada.
² Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Canada; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Canada. Electronic address: daniela.quail@mcgill.ca.
³ Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Canada; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Canada; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Canada; Department of Surgery, Faculty of Medicine, McGill University, Montreal, Canada. Electronic address: jonathan.spicer@mcgill.ca.

PMID: 32781042
DOI: 10.1016/j.ccell.2020.07.002

Abstract

Neutrophil extracellular traps (NETs) have been implicated in a wide array of biological processes extending beyond the containment of infection, including metastatic dissemination. A recent publication in Nature highlights a NETs-dependent mechanism that directly enhances the invasive and proliferative properties of cancer cells.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

DNA
Extracellular Traps*
Neutrophils*

Substances

DNA

Grants and funding

CIHR/Canada