CONAN: a web application to detect specificity determinants and functional sites by amino acids co-variation network analysis

N J Fonseca; M Q L Afonso; L Carrijo; L Bleicher

doi:10.1093/bioinformatics/btaa713

CONAN: a web application to detect specificity determinants and functional sites by amino acids co-variation network analysis

Bioinformatics. 2021 May 17;37(7):1026-1028. doi: 10.1093/bioinformatics/btaa713.

Authors

N J Fonseca^{1

2}, M Q L Afonso², L Carrijo², L Bleicher²

Affiliations

¹ Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
² Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.

PMID: 32780795
DOI: 10.1093/bioinformatics/btaa713

Abstract

Summary: CONAN is a web application developed to detect specificity determinants and function-related sites by amino acids co-variation networks analysis, emphasizing local coevolutionary constraints. The software allows the characterization of structurally and functionally relevant groups of residues and their relationship with subsets of sequences by automatic cross-referencing with GO terms, UniprotKb annotations and INTERPRO.

Availability and implementation: CONAN is free and open-source, being distributed in the terms of the GPLV3 license. The software is available as a web application and python script versions and can be accessed at http://bioinfo.icb.ufmg.br/conan. We also provide running instructions, the source code and a user guide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids*
Software*

Substances

Amino Acids