The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma; Zoltan Gombos; Matyas Jokai; Istvan Berkes; Masaki Takeda; Tatsuya Mimura; Zsolt Radak; Ferenc Gyori

doi:10.1016/j.jshs.2020.03.004

The roles of microRNA in redox metabolism and exercise-mediated adaptation

J Sport Health Sci. 2020 Sep;9(5):405-414. doi: 10.1016/j.jshs.2020.03.004. Epub 2020 Mar 19.

Authors

Ferenc Torma¹, Zoltan Gombos¹, Matyas Jokai¹, Istvan Berkes¹, Masaki Takeda², Tatsuya Mimura³, Zsolt Radak⁴, Ferenc Gyori⁵

Affiliations

¹ Research Center of Molecular Exercise Science, University of Physical Education, Budapest 1123, Hungary.
² Faculty of Health and Sports Science, Doshisha University, Kyotanabe 610-0394, Japan.
³ Faculty of Sport and Health Sciences, Osaka Sangyo University, Osaka 573-1004, Japan.
⁴ Research Center of Molecular Exercise Science, University of Physical Education, Budapest 1123, Hungary; Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan; Institute of Physical Education and Sport Science, JGYPK, University of Szeged, Szeged 6726, Hungary. Electronic address: radak.zsolt@tf.hu.
⁵ Institute of Physical Education and Sport Science, JGYPK, University of Szeged, Szeged 6726, Hungary.

Abstract

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

Keywords: Adaptation; Exercise; MicroRNA; Oxidative damage; Reactive oxygen species; Redox regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptation, Physiological*
Animals
Exercise / physiology*
Humans
MicroRNAs / metabolism*
Muscle, Skeletal / metabolism*
Organelle Biogenesis
Oxidation-Reduction*
Oxidative Stress
Reactive Oxygen Species / metabolism
Signal Transduction

Substances

MicroRNAs
Reactive Oxygen Species