Minimizing disease spread on a quarantined cruise ship: A model of COVID-19 with asymptomatic infections

Math Biosci. 2020 Nov:329:108442. doi: 10.1016/j.mbs.2020.108442. Epub 2020 Aug 7.

Abstract

On February 5 the Japanese government ordered the passengers and crew on the Diamond Princess to start a two week quarantine after a former passenger tested positive for COVID-19. During the quarantine the virus spread rapidly throughout the ship. By February 20, there were 651 cases. We model this quarantine with a SEIR model including asymptomatic infections with differentiated shipboard roles for crew and passengers. The study includes the derivation of the basic reproduction number and simulation studies showing the effect of quarantine with COVID-19 or influenza on the total infection numbers. We show that quarantine on a ship with COVID-19 will lead to significant disease spread if asymptomatic infections are not identified. However, if the majority of the crew and passengers are immune or vaccinated to COVID-19, then quarantine would slow the spread. We also show that a disease similar to influenza, even with a ship with a fully susceptible crew and passengers, could be contained through quarantine measures.

Keywords: Asymptomatic; COVID-19; Cruise ship; Flu; Isolation; Quarantine; Reproduction number; SEIR; Sensitivity.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Asymptomatic Infections*
  • Basic Reproduction Number / statistics & numerical data
  • Betacoronavirus*
  • COVID-19
  • COVID-19 Testing
  • Clinical Laboratory Techniques
  • Communicable Diseases, Imported / prevention & control
  • Communicable Diseases, Imported / transmission
  • Computer Simulation
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / prevention & control*
  • Coronavirus Infections / transmission*
  • Humans
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control
  • Influenza, Human / transmission
  • Japan / epidemiology
  • Mathematical Computing
  • Models, Biological
  • Pandemics / prevention & control*
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / prevention & control*
  • Pneumonia, Viral / transmission*
  • Quarantine* / methods
  • SARS-CoV-2
  • Ships*
  • Travel Medicine
  • Travel*
  • Travel-Related Illness