An analysis of SARS-CoV-2 cell entry genes identifies the intestine and colorectal cancer as susceptible tissues

Br J Surg. 2020 Oct;107(11):e452-e454. doi: 10.1002/bjs.11911. Epub 2020 Aug 10.

Authors

Mahnaz Darvish-Damavandi¹, James Laycock², Christopher Ward¹, Milou S van Driel¹, Mae A Goldgraben³, Simon Ja Buczacki^{1

2}

Affiliations

¹ Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge, UK.
² Cambridge Colorectal Unit, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, UK.
³ Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge, UK.

No abstract available

Publication types

Letter

MeSH terms

Angiotensin-Converting Enzyme 2 / metabolism*
COVID-19 / metabolism
Colorectal Neoplasms / metabolism*
Disease Susceptibility
Humans
Intestinal Mucosa / metabolism*
Receptors, Virus / metabolism
SARS-CoV-2 / physiology*
Serine Endopeptidases / metabolism*
Tissue Donors
Virus Internalization*

Substances

Receptors, Virus
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human

Grants and funding