Abstract
Proliferative nodules arising within congenital melanocytic nevi often present a diagnostic challenge given a close resemblance to melanoma. Several morphologic variants have been characterized. In difficult cases, ancillary molecular tests can be used to better exclude the possibility of malignant degeneration. Herein, we report a case of an unusual proliferative nodule with overlapping features of angiomatoid Spitz tumor and ancient melanocytic nevus, which demonstrated normal findings on both chromosomal microarray and a gene expression profiling assay.
Keywords:
ancient nevus; angiomatoid Spitz; congenital melanocytic nevi; malignant melanoma; proliferative nodule.
© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
MeSH terms
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Angiomatosis / pathology*
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Biopsy
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Black or African American / ethnology
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Cell Proliferation
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Child
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Diagnosis, Differential
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Gene Expression Profiling / methods
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Histones / metabolism
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Humans
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Hyperpigmentation / pathology
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Immunohistochemistry / methods
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Knee / pathology
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Male
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Melanoma / pathology
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Nevus, Pigmented / congenital*
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Nevus, Pigmented / diagnosis
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Nevus, Pigmented / metabolism
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Nevus, Pigmented / pathology
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Nevus, Pigmented / surgery
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SOXE Transcription Factors / metabolism
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Skin Neoplasms / diagnosis
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Skin Neoplasms / metabolism
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Skin Neoplasms / pathology*
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Skin Neoplasms / surgery
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Tumor Suppressor Proteins / metabolism
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Ubiquitin Thiolesterase / metabolism
Substances
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BAP1 protein, human
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Histones
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SOX10 protein, human
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SOXE Transcription Factors
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Tumor Suppressor Proteins
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histone H3 trimethyl Lys4
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Ubiquitin Thiolesterase
Supplementary concepts
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Melanocytic nevus syndrome, congenital