The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

Shou Wang; Kazuyo Igawa; Ryo Ogawara; Mitsuru Suda; Tsuyoshi Hamano; Soichiro Ibaragi; Tadashi Hanafusa; Yasuaki Ichikawa; Akira Sasaki

doi:10.1016/j.apradiso.2020.109271

The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

Appl Radiat Isot. 2020 Nov:165:109271. doi: 10.1016/j.apradiso.2020.109271. Epub 2020 Jul 6.

Authors

Shou Wang¹, Kazuyo Igawa², Ryo Ogawara³, Mitsuru Suda⁴, Tsuyoshi Hamano⁴, Soichiro Ibaragi¹, Tadashi Hanafusa⁵, Yasuaki Ichikawa⁵, Akira Sasaki¹

Affiliations

¹ Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata Kita-ku Okayama, 700-855, Japan.
² Neutron Therapy Research Center, Okayama University, 2-5-1 Shikata Kita-ku Okayama, 700-855, Japan. Electronic address: igawakazuyo@okayama-u.ac.jp.
³ Advanced Research Center for Beam Science, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
⁴ National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
⁵ Neutron Therapy Research Center, Okayama University, 2-5-1 Shikata Kita-ku Okayama, 700-855, Japan.

PMID: 32771869
DOI: 10.1016/j.apradiso.2020.109271

Abstract

The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening.

Keywords: BNCR; BPA; Head and neck cancer; Osteosarcoma; SCC.

MeSH terms

Boron Neutron Capture Therapy / methods*
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / radiotherapy*
Cell Line, Tumor
Head and Neck Neoplasms / pathology
Head and Neck Neoplasms / radiotherapy*
Humans
Osteosarcoma / pathology*
Particle Accelerators*