Synchronous Malignancies Identified by 18F-fluciclovine Positron Emission Tomography for Prostate Cancer: Case Series and Mini-Review

John M Hoyle; Andrew Lenzie; Samuel J Galgano; Jonathan E McConathy; Soroush Rais-Bahrami; Jeffrey W Nix; Andrew M McDonald

doi:10.1016/j.clgc.2020.07.009

Synchronous Malignancies Identified by ¹⁸F-fluciclovine Positron Emission Tomography for Prostate Cancer: Case Series and Mini-Review

Clin Genitourin Cancer. 2021 Feb;19(1):e37-e40. doi: 10.1016/j.clgc.2020.07.009. Epub 2020 Jul 16.

Authors

John M Hoyle¹, Andrew Lenzie¹, Samuel J Galgano², Jonathan E McConathy², Soroush Rais-Bahrami³, Jeffrey W Nix³, Andrew M McDonald⁴

Affiliations

¹ School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
² Department of Radiology, University of Alabama at Birmingham, Birmingham, AL; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
³ O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL; Department of Urology, University of Alabama at Birmingham, Birmingham, AL.
⁴ O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL. Electronic address: ammcdonald@uabmc.edu.

PMID: 32771333
DOI: 10.1016/j.clgc.2020.07.009

Abstract

Positron emission tomography using the fluorine-18 (¹⁸F) fluciclovine radiotracer has been approved for use in recurrent prostate cancer and is a useful tool for clinical decision making. However, ¹⁸F-fluciclovine is not specific for prostate cancer tumor cells, and false-positive results have been reported. In the present study, we have reported our experience with synchronous malignancies identified using ¹⁸F-fluciclovine and reviewed other reported cases, with a special emphasis on highlighting the clinical decisions that led to the correct diagnosis.

Keywords: Cancer imaging; Diagnosis; Fluorine-18 fluciclovine; Positron emission tomography; Synchronous malignancy.

Publication types

Review

MeSH terms

Carboxylic Acids
Cyclobutanes*
Humans
Male
Neoplasm Recurrence, Local
Neoplasms, Multiple Primary*
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Prostatic Neoplasms* / diagnostic imaging
Radiopharmaceuticals

Substances

Carboxylic Acids
Cyclobutanes
Radiopharmaceuticals