The immune-sleep crosstalk in inflammatory bowel disease

Nour Eissa; Quais Mujawar; Tareq Alabdoulsalam; Sahar Zohni; Wael El-Matary

doi:10.1016/j.sleep.2020.04.020

The immune-sleep crosstalk in inflammatory bowel disease

Sleep Med. 2020 Sep:73:38-46. doi: 10.1016/j.sleep.2020.04.020. Epub 2020 Apr 30.

Authors

Nour Eissa¹, Quais Mujawar², Tareq Alabdoulsalam², Sahar Zohni³, Wael El-Matary⁴

Affiliations

¹ Department of Immunology, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; Department of Internal Medicine, Section of Gastroenterology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Nour.Eissa@umanitoba.ca.
² Department of Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada.
³ Department of Pediatrics, Faculty of Medicine, University of Alexandria, Alexandria, Egypt; Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁴ Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada; Department of Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada.

PMID: 32769031
DOI: 10.1016/j.sleep.2020.04.020

Abstract

Sleep disorders are progressively common and sometimes are associated with aberrant regulation of the adaptive and innate immune responses. Sleep interruption can increase the inflammatory burden by enhancing the pro-inflammatory cytokines particularly in patients with chronic diseases such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disease characterized by immune dysregulation, dysbiosis of gut microbiome, and poor-quality life. Therefore, this review highlights the crosstalk between sleep and immune responses during the progression of IBD.

Keywords: Cytokines; Intestinal inflammation; Sleep disorders.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cytokines
Dysbiosis / complications
Gastrointestinal Microbiome*
Humans
Inflammatory Bowel Diseases* / complications
Sleep

Substances

Cytokines

Grants and funding

395678/CIHR/Canada