Targeting Tumor-Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies

Hepatology. 2021 Feb;73(2):821-832. doi: 10.1002/hep.31502.

Authors

Ligong Lu¹, Jun Jiang², Meixiao Zhan¹, Hui Zhang³, Qian-Ting Wang², Sheng-Nan Sun², Xiao-Kai Guo², Hua Yin¹, Yadong Wei⁴, Shi-You Li², Jun O Liu⁴, Yong Li¹, You-Wen He⁵

Affiliations

¹ Zhuhai Interventional Medical CenterZhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhaiGuangdong ProvinceP.R. China.
² Tricision Biotherapeutic Inc. Jinwan DistrictZhuhaiChina.
³ First Affiliated HospitalChina Medical UniversityShenyangChina.
⁴ Department of Pharmacology and Molecular SciencesJohns Hopkins University School of MedicineBaltimoreMD.
⁵ Department of ImmunologyDuke University Medical University Medical CenterDurhamNC.

PMID: 32767586
DOI: 10.1002/hep.31502

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antigens, Neoplasm / metabolism*
Antineoplastic Agents, Immunological / pharmacology
Antineoplastic Agents, Immunological / therapeutic use
Cancer Vaccines / therapeutic use
Carcinoma, Hepatocellular / genetics
Carcinoma, Hepatocellular / immunology
Carcinoma, Hepatocellular / mortality
Carcinoma, Hepatocellular / therapy*
Clinical Trials as Topic
Disease-Free Survival
Humans
Immunotherapy / methods*
Immunotherapy / trends
Liver Neoplasms / genetics
Liver Neoplasms / immunology
Liver Neoplasms / mortality
Liver Neoplasms / therapy*
Molecular Targeted Therapy / methods
Molecular Targeted Therapy / trends
Mutation
Neoplasm Recurrence, Local / epidemiology*
Neoplasm Recurrence, Local / genetics
Neoplasm Recurrence, Local / immunology
Neoplasm Recurrence, Local / prevention & control
T-Lymphocytes, Cytotoxic / drug effects
T-Lymphocytes, Cytotoxic / immunology

Substances

Antigens, Neoplasm
Antineoplastic Agents, Immunological
Cancer Vaccines