Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Milan R Savani; Kalil G Abdullah; Samuel K McBrayer

doi:10.1016/j.molcel.2020.07.014

Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

Mol Cell. 2020 Aug 6;79(3):368-370. doi: 10.1016/j.molcel.2020.07.014.

Authors

Milan R Savani¹, Kalil G Abdullah², Samuel K McBrayer³

Affiliations

¹ Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
³ Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: samuel.mcbrayer@utsouthwestern.edu.

PMID: 32763225
DOI: 10.1016/j.molcel.2020.07.014

Abstract

A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair.

Publication types

Comment

MeSH terms

DNA Damage*
DNA Repair
Epigenesis, Genetic
Epigenomics
Humans
Neoplasms / genetics*