Polyspike ictal-onset absence seizures in a pediatric patient with Down syndrome

Sherouk Abdelmoity; Mohammed Ilyas

doi:10.1016/j.ebr.2020.100376

Polyspike ictal-onset absence seizures in a pediatric patient with Down syndrome

Epilepsy Behav Rep. 2020 Jul 2:14:100376. doi: 10.1016/j.ebr.2020.100376. eCollection 2020.

Authors

Sherouk Abdelmoity^{1

2}, Mohammed Ilyas^{1

2}

Affiliations

¹ Department of Neurology, Epilepsy Center, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital, Kansas City, MO, United States of America.
² Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Children's Mercy Hospital, Kansas City, MO, United States of America.

Abstract

Polyspike ictal-onset absence seizure has been reported in adult patients with genetic generalized epilepsy but is a novel pattern in the pediatric population. Absence seizures are usually associated with generalized spike-and-wave on EEG. However, we present the case of a 10-year-old girl with Down syndrome and developmental delays who presented with atypical absence seizure associated with an unusual electroencephalographic (EEG) pattern of polyspike ictal-onset. Recognition of this ictal pattern in the pediatric population, as previously reported in adult populations, is important as it can have therapeutic and prognostic implications.

Keywords: Absence seizure; Down syndrome; Ictal pattern; Polyspike ictal-onset.

Publication types

Case Reports