Lung Screen Uptake Trial: results from a single lung cancer screening round

Mamta Ruparel; Samantha L Quaife; Jennifer L Dickson; Carolyn Horst; Sophie Tisi; Helen Hall; Magali Taylor; Asia Ahmed; Penny Shaw; Stephen Burke; May-Jan Soo; Arjun Nair; Anand Devaraj; Karen Sennett; Stephen W Duffy; Neal Navani; Angshu Bhowmik; David R Baldwin; Sam M Janes

doi:10.1136/thoraxjnl-2020-214703

Lung Screen Uptake Trial: results from a single lung cancer screening round

Thorax. 2020 Oct;75(10):908-912. doi: 10.1136/thoraxjnl-2020-214703. Epub 2020 Aug 5.

Authors

Mamta Ruparel¹, Samantha L Quaife², Jennifer L Dickson¹, Carolyn Horst¹, Sophie Tisi¹, Helen Hall¹, Magali Taylor³, Asia Ahmed³, Penny Shaw³, Stephen Burke⁴, May-Jan Soo⁴, Arjun Nair³, Anand Devaraj⁵, Karen Sennett⁶, Stephen W Duffy⁷, Neal Navani^{1

8}, Angshu Bhowmik⁹, David R Baldwin¹⁰, Sam M Janes¹¹

Affiliations

¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK.
² Research Department of Behavioural Science and Health, University College London, London, UK.
³ Department of Radiology, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁴ Department of Radiology, Homerton University Hospital NHS Foundation Trust, London, London, UK.
⁵ Department of Radiology, Royal Brompton Hospital, London, UK.
⁶ Killick Street Health Centre, London, UK.
⁷ Wolfson Institute of Preventive Medicine, Barts and London, London, UK.
⁸ Thoracic Medicine Department, University College London Hospitals NHS Foundation Trust, London, London, UK.
⁹ Respiratory Medicine, Homerton University Hospital NHS Foundation Trust, London, London, UK.
¹⁰ Respiratory Medicine Unit, David Evans Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK.
¹¹ Lungs for Living Research Centre, UCL Respiratory, University College London, London, England, UK s.janes@ucl.ac.uk.

Abstract

The Lung Screen Uptake Trial tested a novel invitation strategy to improve uptake and reduce socioeconomic and smoking-related inequalities in lung cancer screening (LCS) participation. It provides one of the first UK-based 'real-world' LCS cohorts. Of 2012 invited, 1058 (52.6%) attended a 'lung health check'. 768/996 (77.1%) in the present analysis underwent a low-dose CT scan. 92 (11.9%) and 33 (4.3%) participants had indeterminate pulmonary nodules requiring 3-month and 12-month surveillance, respectively; 36 lung cancers (4.7%) were diagnosed (median follow-up: 1044 days). 72.2% of lung cancers were stage I/II and 79.4% of non-small cell lung cancer had curative-intent treatment.

Keywords: imaging/CT MRI etc; lung cancer.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carcinoma / diagnosis*
Cohort Studies
Early Detection of Cancer*
Female
Humans
Lung Neoplasms / diagnosis*
Male
Middle Aged
Neoplasm Staging
Patient Acceptance of Health Care*
Radiation Dosage
Socioeconomic Factors
United Kingdom

Abstract

Publication types

MeSH terms

Grants and funding