Mitochondria (cross)talk with proteostatic mechanisms: Focusing on ageing and neurodegenerative diseases

Abstract

Perturbations of proteostatic mechanisms and mitochondrial decline during ageing and neurodegenerative diseases are well-established. Nevertheless, only a handful of interventions boosting proteostasis and mitochondrial function have been shown to delay ageing while therapies against neurodegeneration are still unavailable. Increasing evidence links the function of proteostatic mechanisms with each other and with the mitochondrial network. Tracing of this complex crosstalking network might lead to effective anti-ageing or neurodegenerative disease-modifying approaches. In this review we present evidence on the crosstalk of proteostatic mechanisms with mitochondria and discuss how incorporating this knowledge in future studies may help us develop more efficacious interventions against ageing and neurodegeneration.

Keywords: Ageing; Autophagy-lysosomal pathway (ALP); Crosstalk; Mitochondria; Neurodegeneration; Ubiquitin-proteasome system (UPS).