p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology

J Am Heart Assoc. 2020 Aug 4;9(15):e017247. doi: 10.1161/JAHA.120.017247. Epub 2020 Jul 29.
No abstract available

Keywords: cardiac metabolism; cardiotoxicity; doxorubicin; p53.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / adverse effects*
  • Apelin Receptors / metabolism*
  • Cardiotoxicity
  • Doxorubicin / adverse effects*
  • Energy Metabolism / drug effects
  • Fatty Acids / metabolism
  • Heart / drug effects
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Myocardium / metabolism*
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism*
  • Signal Transduction / drug effects
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Antibiotics, Antineoplastic
  • Apelin Receptors
  • Fatty Acids
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Tumor Suppressor Protein p53
  • Doxorubicin

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