Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility

Jiao Zhao; Yan Yang; Hanping Huang; Dong Li; Dongfeng Gu; Xiangfeng Lu; Zheng Zhang; Lei Liu; Ting Liu; Yukun Liu; Yunjiao He; Bin Sun; Meilan Wei; Guangyu Yang; Xinghuan Wang; Li Zhang; Xiaoyang Zhou; Mingzhao Xing; Peng George Wang

doi:10.1093/cid/ciaa1150

Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility

Clin Infect Dis. 2021 Jul 15;73(2):328-331. doi: 10.1093/cid/ciaa1150.

Authors

Jiao Zhao¹, Yan Yang², Hanping Huang³, Dong Li⁴, Dongfeng Gu¹, Xiangfeng Lu⁵, Zheng Zhang², Lei Liu², Ting Liu³, Yukun Liu⁶, Yunjiao He¹, Bin Sun¹, Meilan Wei¹, Guangyu Yang⁷, Xinghuan Wang⁸, Li Zhang³, Xiaoyang Zhou⁴, Mingzhao Xing¹, Peng George Wang¹

Affiliations

¹ School of Medicine, The Southern University of Science and Technology, Shenzhen, People's Republic of China.
² National Clinical Research Center for Infectious Diseases, The Second Affiliated Hospital School of Medicine, Southern University of Science and Technology; Shenzhen Third People's Hospital, Shenzhen, People's Republic of China.
³ Department of Infectious Diseases, Wuhan Jinyintan Hospital, Wuhan, People's Republic of China.
⁴ Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
⁵ Department of Epidemiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
⁶ School of Statistics, East China Normal University, Shanghai, People's Republic of China.
⁷ School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
⁸ Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.

Abstract

To explore any relationship between the ABO blood group and the coronavirus disease 2019 (COVID-19) susceptibility, we compared ABO blood group distributions in 2173 COVID-19 patients with local control populations, and found that blood group A was associated with an increased risk of infection, whereas group O was associated with a decreased risk.

Keywords: ABO blood group; COVID-19; SARS-CoV-2; coronavirus; disease susceptibility.

MeSH terms

ABO Blood-Group System*
COVID-19*
Disease Susceptibility
Humans
Retrospective Studies
SARS-CoV-2

Substances

ABO Blood-Group System