Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice

Protein Cell. 2020 Oct;11(10):776-782. doi: 10.1007/s13238-020-00767-x.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Adenosine Monophosphate / administration & dosage
  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / pharmacology
  • Adenosine Monophosphate / therapeutic use
  • Administration, Intranasal
  • Alanine / administration & dosage
  • Alanine / analogs & derivatives
  • Alanine / pharmacology
  • Alanine / therapeutic use
  • Animals
  • Betacoronavirus / genetics
  • Betacoronavirus / physiology*
  • COVID-19
  • COVID-19 Drug Treatment
  • Chlorocebus aethiops
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / virology*
  • Disease Models, Animal*
  • Female
  • Host Specificity* / genetics
  • Lung / pathology
  • Lung / virology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mutation, Missense
  • Nasal Mucosa / virology
  • Pandemics
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / virology*
  • RNA, Viral / administration & dosage
  • RNA, Viral / genetics
  • SARS-CoV-2
  • Turbinates / virology*
  • Vero Cells
  • Viral Load
  • Virus Replication

Substances

  • RNA, Viral
  • remdesivir
  • Adenosine Monophosphate
  • Alanine