Abstract
Cystine/glutamic acid reverse transporter (System Xc - ), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against oxidative stress and ferroptosis. Studies have confirmed that xCT is highly expressed in a variety of tumour and is associated with tumour proliferation, invasion, metastasis, drug resistance and ferroptosis, and can be used as a potential target for tumour treatment. This review provides insights into the biological effects of xCT and contribute to the development of new xCT-based strategies.
Keywords:
cancer; ferroptosis; oxidative stress; system Xc−; xCT.
© 2020 John Wiley & Sons Ltd.
MeSH terms
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Amino Acid Transport System y+ / antagonists & inhibitors
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Amino Acid Transport System y+ / genetics
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Amino Acid Transport System y+ / metabolism*
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Ferroptosis / drug effects
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Glutathione / metabolism
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Humans
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Neoplasms / drug therapy
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Neoplasms / metabolism
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Neoplasms / pathology*
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Oxidative Stress / drug effects
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RNA, Small Interfering / metabolism
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RNA, Small Interfering / therapeutic use
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Reactive Oxygen Species / metabolism
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Sulfasalazine / metabolism
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Sulfasalazine / pharmacology
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Sulfasalazine / therapeutic use
Substances
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Amino Acid Transport System y+
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Anti-Inflammatory Agents, Non-Steroidal
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RNA, Small Interfering
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Reactive Oxygen Species
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SLC7A11 protein, human
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Sulfasalazine
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Glutathione