Abstract
Traumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduces PTEN expression in adult sensory neurons; however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons.
Keywords:
IB4-positive neurons; PTEN; axon regeneration; sensory neuron.
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Down-Regulation / drug effects
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Ganglia, Spinal / cytology
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Gene Expression Regulation / drug effects
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Mice
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Mice, Knockout
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Nerve Regeneration / drug effects
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Nerve Regeneration / physiology*
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Nerve Tissue Proteins / antagonists & inhibitors*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / genetics
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Neuronal Outgrowth / drug effects
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Neuronal Outgrowth / physiology*
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PTEN Phosphohydrolase / antagonists & inhibitors*
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PTEN Phosphohydrolase / deficiency
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PTEN Phosphohydrolase / physiology
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Phenanthrenes / pharmacology*
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Plant Lectins / analysis*
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Sciatic Neuropathy / physiopathology*
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Sensory Receptor Cells / chemistry
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Sensory Receptor Cells / classification
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Sensory Receptor Cells / drug effects
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Sensory Receptor Cells / metabolism*
Substances
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Griffonia simplicifolia lectins
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Nerve Tissue Proteins
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Phenanthrenes
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Plant Lectins
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RNA, Messenger
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SF1670
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PTEN Phosphohydrolase
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Pten protein, mouse