Lignan compound isolated from n-Hexane extract myristica fragrans Houtt root as antioxidant and antitumor activities against MCF-7 cell lines data

Binawati Ginting; Nurdin Saidi; Murniana; Mustanir; Maulidna; Partomuan Simanjuntak

doi:10.1016/j.dib.2020.105997

Lignan compound isolated from n-Hexane extract myristica fragrans Houtt root as antioxidant and antitumor activities against MCF-7 cell lines data

Data Brief. 2020 Jul 5:31:105997. doi: 10.1016/j.dib.2020.105997. eCollection 2020 Aug.

Authors

Binawati Ginting¹, Nurdin Saidi¹, Murniana¹, Mustanir¹, Maulidna², Partomuan Simanjuntak³

Affiliations

¹ Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.
² Politeknik Teknologi Kimia Industri, Medan 20228, Indonesia.
³ Research Centre for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek Serpong, Tangerang Selatan, Banten, Indonesia.

Abstract

Nutmeg plant (Myristica fragrans Houtt) is known as one of traditional medicine. The nutmeg root has a strong potential in antioxidant and anticancer agents among other nutmeg plant parts. The n-hexane root extract has been carried out by thin-layer chromatography and obtained 8 fractions (labeled as Myristica fragrans Houtt Root: MFHR 1 - 8). Specifically, the MFHR 4 has been purified for several times to obtain a yellow-brown color. Furthermore, lignan compound 6'-methyl-(7‑hydroxy-8-methylbut-9-en)-3,2'-dimethoxybiphenyl-4,5-diol) was identified with chemical formula of C₂₀H₂₄O₅ and analyzed using UV-vis spectroscopy, fourier-transform infrared spectroscopy (FTIR), 1D/2D nuclear magnetic resonance (NMR), and liquid chromatography-mass spectrometry (LC-MS). Based on MTT assay, MFHR demonstrated moderate anticancer activity against MCF-7 cell lines of 51.95 µM, meanwhile, DPPH activity confirmed the strong antioxidant activity with IC50 value of 12.67 ppm.

Keywords: Anticancer; Antioxidant; Lignan; N-hexane extract; Nutmeg root.