Hydralazine-Induced Dual Antineutrophil Cytoplasmic Antibody Positive Vasculitis and Nephritis

Sandeep A Padala; Vidya M Medepalli; Azeem Mohammed; Stanley Nahman

doi:10.7759/cureus.8911

Hydralazine-Induced Dual Antineutrophil Cytoplasmic Antibody Positive Vasculitis and Nephritis

Cureus. 2020 Jun 29;12(6):e8911. doi: 10.7759/cureus.8911.

Authors

Sandeep A Padala¹, Vidya M Medepalli², Azeem Mohammed¹, Stanley Nahman¹

Affiliations

¹ Nephrology, Augusta University Medical College of Georgia, Augusta, USA.
² Medicine, Augusta University Medical College of Georgia, Augusta, USA.

Abstract

Drug-induced autoimmunity occurs when exposure to a causative agent leads to serologic or clinical autoimmune responses. Syndromes that may be associated with drug-induced autoimmunity include antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and drug-induced lupus (DIL). When drug-induced autoimmunity involves the kidney, histological patterns of injury include pauci-immune glomerulonephritis (GN), which occurs with AAV, and immune complex-mediated GN, which is associated with DIL. We present a case of hydralazine-induced dual ANCA-positive vasculitis and nephritis.

Keywords: acute kidney injury (aki); antineutrophil cytoplasmic antibody (anca); antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav); drug-induced lupus (dil); dual anca aav and dil; hydralazine; hydralazine induced dual aav and dil; pauci-immune glomerulonephritis (gn).

Publication types

Case Reports