New core configuration for the fabrication of 125I radioactive sources for cancer treatment

Carla Daruich de Souza; Carlos Alberto Zeituni; Anselmo Feher; João Augusto Moura; Osvaldo Luiz da Costa; Lucas Verdi Angelocci; Maria Elisa C M Rostelato

doi:10.1016/j.apradiso.2020.109307

New core configuration for the fabrication of ¹²⁵I radioactive sources for cancer treatment

Appl Radiat Isot. 2020 Nov:165:109307. doi: 10.1016/j.apradiso.2020.109307. Epub 2020 Jul 20.

Authors

Carla Daruich de Souza¹, Carlos Alberto Zeituni², Anselmo Feher³, João Augusto Moura⁴, Osvaldo Luiz da Costa⁵, Lucas Verdi Angelocci⁶, Maria Elisa C M Rostelato⁷

Affiliations

¹ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: carladdsouza@yahoo.com.br.
² Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: czeituni@ipen.br.
³ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: afeher@ipen.br.
⁴ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: jamoura@ipen.br.
⁵ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: olcosta@ipen.br.
⁶ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: lucasangelocci@usp.br.
⁷ Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, Avenida Professor Lineu Prestes, 2242 Zip-code: 05508-000, São Paulo, SP, Brazil. Electronic address: elisaros@ipen.br.

PMID: 32738753
DOI: 10.1016/j.apradiso.2020.109307

Abstract

In order to provide prostate brachytherapy treatment for more Brazilian men, IPEN is building a laboratory for the manufacture of radioactive sources. The new methodology for the production of iodine-125 seeds with yield 71.7% ± 5.3%. Points of importance were evaluated/discussed: photo-sensibility, reaction vial type, the substitution for iodine-131, pH, and solution volume. The surface was analyzed by FTIR and EDS. At the end, a Monte Carlo-MCNP6 simulation was performed to evaluate the TG-43 parameters.

Keywords: Brachytherapy; Iodine-125 seed core; Monte Carlo simulation; Radiation chemistry.

MeSH terms

Brachytherapy / methods
Humans
Iodine Radioisotopes / administration & dosage
Iodine Radioisotopes / therapeutic use*
Male
Monte Carlo Method
Neoplasms / radiotherapy*
Prostatic Neoplasms / radiotherapy*
Spectrometry, X-Ray Emission
Spectroscopy, Fourier Transform Infrared

Substances

Iodine Radioisotopes