Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy

Fenfen Li; Tuanwei Li; Debo Zhi; Pengping Xu; Wenshen Wang; Yi Hu; Yuanyuan Zhang; Shaozhen Wang; J Matula Thomas; J Beauchamp Norman; Weiping Ding; Lifeng Yan; Bensheng Qiu

doi:10.1016/j.biomaterials.2020.120219

Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy

Biomaterials. 2020 Oct:256:120219. doi: 10.1016/j.biomaterials.2020.120219. Epub 2020 Jul 1.

Authors

Fenfen Li¹, Tuanwei Li², Debo Zhi¹, Pengping Xu², Wenshen Wang¹, Yi Hu¹, Yuanyuan Zhang¹, Shaozhen Wang¹, J Matula Thomas³, J Beauchamp Norman⁴, Weiping Ding⁵, Lifeng Yan⁶, Bensheng Qiu⁷

Affiliations

¹ Hefei National Lab for Physical Sciences at the Microscale and Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230027, China.
² CAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026, China.
³ Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA, 98105, USA.
⁴ The College of Human Medicine Michigan State University, Grand Rapids, MI, 49503, USA.
⁵ Hefei National Lab for Physical Sciences at the Microscale and Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230027, China. Electronic address: wpdings@ustc.edu.cn.
⁶ CAS Key Laboratory of Soft Matter Chemistry, iChEM, and Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address: lfyan@ustc.edu.cn.
⁷ Hefei National Lab for Physical Sciences at the Microscale and Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, 230027, China. Electronic address: bqiu@ustc.edu.cn.

PMID: 32736173
DOI: 10.1016/j.biomaterials.2020.120219

Abstract

Encouraging progress in multifunctional nanotheranostic agents that combine photothermal therapy (PTT) and different imaging modalities has been made. However, rational designed and biocompatible multifunctional agents that suitfable for in vivo application is highly desired but still challenging. In this work, we rationally designed novel ultrasmall multifunctional nanodots (FS-GdNDs) by combining the bovine serum albumin (BSA)-based gadolinium oxide nanodots (GdNDs) obtained through a biomineralization process with a small-molecule NIR-II fluorophore (FS). The as-prepared FS-GdNDs with an ultrasmall hydrodynamic diameter of 9.3 nm exhibited prominent NIR-II fluorescence properties, high longitudinal relaxivity (10.11 mM^-1 s^-1), and outstanding photothermal conversion efficiency (43.99%) and photothermal stability. In vivo studies showed that the FS-GdNDs with enhanced multifunctional characteristics diaplayed satisfactory dual-modal MR/NIR-II imaging performance with a quite low dose. The imaging-guided PTT achieved successful ablation of tumors and effectively extended the survival of mice. Cytotoxicity studies and histological assay demonstrated excellent biocompatibility of the nanodots. Importantly, this novel FS-GdNDs can undergo efficient body clearance through both hepatobiliary and renal excretion pathways. The novel ultrasmall multifunctional FS-GdNDs with excellent features hold tremendous potential in biomedical and clinical applications.

Keywords: Biomineralization; Imaging guidance; MR/NIR-II imaging; NIR-II fluorophore; Photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Magnetic Resonance Imaging
Mice
Nanostructures
Neoplasms* / therapy
Phototherapy*
Photothermal Therapy
Serum Albumin, Bovine

Substances

Serum Albumin, Bovine