Evaluation of two different mutations in codon 12 of NRAS gene in ulcerated penile mucosal nodular malignant melanoma pT4b of the 90-year-old man in perspective of targeted therapy of NRAS-mutated advanced melanomas

Dermatol Ther. 2020 Nov;33(6):e14115. doi: 10.1111/dth.14115. Epub 2020 Sep 4.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged, 80 and over
  • Codon
  • GTP Phosphohydrolases / genetics
  • Genes, ras
  • Humans
  • Male
  • Melanoma* / drug therapy
  • Melanoma* / genetics
  • Membrane Proteins / genetics
  • Mutation
  • Proto-Oncogene Proteins B-raf / genetics
  • Skin Neoplasms* / drug therapy
  • Skin Neoplasms* / genetics

Substances

  • Codon
  • Membrane Proteins
  • Proto-Oncogene Proteins B-raf
  • GTP Phosphohydrolases
  • NRAS protein, human