An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

Ke Pei; Ting Gui; Dongfang Kan; Huichao Feng; Yanqiang Jin; Ying Yang; Qian Zhang; Ziwei Du; Zhibo Gai; Jibiao Wu; Yunlun Li

doi:10.1155/2020/4020249

An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease

Biomed Res Int. 2020 Jul 18:2020:4020249. doi: 10.1155/2020/4020249. eCollection 2020.

Authors

Ke Pei^#¹, Ting Gui^#^{2

3

4}, Dongfang Kan^{2

3

4}, Huichao Feng⁵, Yanqiang Jin⁶, Ying Yang^{2

3

4}, Qian Zhang⁷, Ziwei Du⁸, Zhibo Gai^{2

3

4

9}, Jibiao Wu¹, Yunlun Li^{7

10}

Affiliations

¹ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
² Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
³ Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁴ Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic research, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁵ Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁶ Traditional Chinese Medicine Department, Tai'an Maternal and Child Health Hospital, Tai'an, China.
⁷ First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁸ Institute of Rehabilitation, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁹ Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.
¹⁰ The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

^# Contributed equally.

Abstract

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.

Publication types

Review

MeSH terms

Animals
Humans
Life Style
Lipid Metabolism*
Liver / metabolism
Liver / pathology
Molecular Targeted Therapy
Non-alcoholic Fatty Liver Disease / metabolism*
Risk Factors