Identification of 9-Core Immune-Related Genes in Bladder Urothelial Carcinoma Prognosis

Lei Na; Yu Bai; Yu Sun; Zhuo Wang; Wei Wang; Lin Yuan; Chenghai Zhao

doi:10.3389/fonc.2020.01142

Identification of 9-Core Immune-Related Genes in Bladder Urothelial Carcinoma Prognosis

Front Oncol. 2020 Jul 8:10:1142. doi: 10.3389/fonc.2020.01142. eCollection 2020.

Authors

Lei Na^{1

2}, Yu Bai^{1

3}, Yu Sun¹, Zhuo Wang¹, Wei Wang¹, Lin Yuan⁴, Chenghai Zhao¹

Affiliations

¹ Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
² Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.
³ Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.
⁴ Liaoning Branch of China Telecom, Shenyang, China.

Abstract

Background: Immune microenvironment within tumors affects initiation, progression and clinical outcome of human cancers. Here we explored an immune-related gene signature associated with prognosis of patients with bladder urothelial carcinoma. Method: The Cancer Genome Atlas (TCGA) database was interrogated for expressions of immune-related genes in bladder urothelial carcinomas. Integrated bioinformatics analyses were performed to identify prognostic factors. Results: Twenty-seven immune-related genes were revealed significantly associated with patient's overall survival (OS) by univariate Cox proportional hazards regression analysis. Nine-core immune-related genes including MMP9, PDGFRA, AHNAK, OLR1, RAC3, IGF1, PGF, OAS1, and SH3BP2 were selected to construct a risk score model by multivariate Cox proportional hazards regression analysis. Bioinformatics analyses further validated that risk score could be used as an important independent factor in evaluating prognosis. Conclusion: We established a prognostic immune signature for patients with bladder urothelial carcinoma, which may provide novel targets for prediction and therapy of these patients.

Keywords: TCGA; bladder urothelial carcinoma (bladder cancer); immune; overall survival; prognosis.