Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

Moustafa Sherief Moustafa; Ramadan Ahmed Mekheimer; Saleh Mohammed Al-Mousawi; Mohamed Abd-Elmonem; Hesham El-Zorba; Afaf Mohamed Abdel Hameed; Tahany Mahmoud Mohamed; Kamal Usef Sadek

doi:10.3762/bjoc.16.142

Microwave-assisted efficient one-pot synthesis of N ²-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

Beilstein J Org Chem. 2020 Jul 16:16:1706-1712. doi: 10.3762/bjoc.16.142. eCollection 2020.

Authors

Moustafa Sherief Moustafa¹, Ramadan Ahmed Mekheimer², Saleh Mohammed Al-Mousawi¹, Mohamed Abd-Elmonem², Hesham El-Zorba³, Afaf Mohamed Abdel Hameed², Tahany Mahmoud Mohamed², Kamal Usef Sadek²

Affiliations

¹ Department of Chemistry, Faculty of Science, Kuwait University, P.O. Box 12613, Safat,13060, Kuwait.
² Department of Chemistry, Faculty of Science, Minia University, Minia 61519, Egypt.
³ Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.

Abstract

An efficient one-pot synthesis of N ²-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of the obtained products.

Keywords: N2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamines; X-ray crystallography; microwave irradiation; one-pot synthesis.

Grants and funding

K. U. Sadek is grateful to the Alexander von Humboldt Foundation for donation of a Milestone START Microwave Labstation. Saleh Al-Mousawi and Moustafa Sherief Moustafa are grateful to the Kuwait Foundation for the Advancement of Science, project number PR1714SC02 for supporting this work. Analytical facilities provided by Kuwait University GFS projects No. GS 01/03 and GS 03/08 are greatly appreciated.