Monitoring Canine Myocardial Infarction Formation and Recovery via Transthoracic Cardiac Strain Imaging

Vincent Sayseng; Rebecca A Ober; Christopher S Grubb; Rachel A Weber; Elisa Konofagou

doi:10.1016/j.ultrasmedbio.2020.06.010

Monitoring Canine Myocardial Infarction Formation and Recovery via Transthoracic Cardiac Strain Imaging

Ultrasound Med Biol. 2020 Oct;46(10):2785-2800. doi: 10.1016/j.ultrasmedbio.2020.06.010. Epub 2020 Jul 27.

Authors

Vincent Sayseng¹, Rebecca A Ober², Christopher S Grubb³, Rachel A Weber¹, Elisa Konofagou⁴

Affiliations

¹ Columbia University, New York, New York, USA.
² Institute of Comparative Medicine, Columbia University, New York, New York, USA.
³ Columbia University Medical Center, New York, New York, USA.
⁴ Columbia University, New York, New York, USA. Electronic address: ek2191@columbia.edu.

Abstract

Myocardial elastography (ME) is an ultrasound-based strain imaging method that aims to determine the degree of ischemia or infarction as a result of the change in the elastic properties of the myocardium. A survival canine model (n = 11) was employed to investigate the ability of ME to image myocardial infarction formation and recovery. Infarcts were generated by ligation of the left anterior descending coronary artery. Canines were survived and imaged for 4 days (n = 7) or 4 weeks (n = 4), allowing sufficient time for recovery via collateral perfusion. A radial strain-based metric, percentage of healthy myocardium by strain (PHM_ε), was developed as a marker for healthy myocardial tissue. PHM_ε was strongly linearly correlated with actual infarct size as determined by gross pathology (R² = 0.80). Mean PHM_ε was reduced 1-3 days post-infarction (p < 0.05) at the papillary and apical short-axis levels; full infarct recovery was achieved by day 28, with mean PHM_ε returning to baseline levels. ME was capable of diagnosing individual myocardial segments as non-infarcted or infarcted with high sensitivity (82%), specificity (92%) and precision (85%) (area under the receiver operating characteristic curve = 0.90). The study therefore strengthens the ME premise that it can detect and assess myocardial infarction progression and recovery in vivo and could thus provide an important role in both disease diagnosis and treatment assesssment.

Keywords: Acute myocardial infarction; Animal model; Strain imaging; Transthoracic echocardiography.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Cardiac Imaging Techniques
Disease Models, Animal
Dogs
Elasticity Imaging Techniques*
Male
Monitoring, Physiologic
Myocardial Infarction / diagnostic imaging*

Abstract

Publication types

MeSH terms

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