Abstract
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales and they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology characteristics and pathological characteristics are also different. We present a comprehensive survey of the latest coronavirus-SARS-CoV-2-from investigating its origin and evolution alongside SARS-CoV. Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review.
Keywords:
COVID-19; Cardiovascular disease; Cytokine storm; Myocardial injury; SARS-CoV-2; Treatment; Venous thromboembolism.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiotensin-Converting Enzyme 2
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Antiviral Agents / therapeutic use
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Asymptomatic Infections
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Betacoronavirus* / chemistry
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Betacoronavirus* / classification
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Betacoronavirus* / pathogenicity
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Betacoronavirus* / physiology
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COVID-19
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COVID-19 Drug Treatment
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COVID-19 Serotherapy
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Comorbidity
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Coronavirus Infections* / drug therapy
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Coronavirus Infections* / epidemiology
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Coronavirus Infections* / immunology
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Coronavirus Infections* / pathology
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Coronavirus Infections* / therapy
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Disease Susceptibility
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Evolution, Molecular
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Genome, Viral
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Humans
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Immunization, Passive
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Pandemics*
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Peptidyl-Dipeptidase A / metabolism
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Pneumonia, Viral* / epidemiology
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Pneumonia, Viral* / immunology
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Pneumonia, Viral* / pathology
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Pneumonia, Viral* / therapy
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Receptors, Coronavirus
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Receptors, Virus / metabolism
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SARS-CoV-2
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Severe acute respiratory syndrome-related coronavirus / chemistry
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Severe acute respiratory syndrome-related coronavirus / classification
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Severe acute respiratory syndrome-related coronavirus / pathogenicity
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Severe acute respiratory syndrome-related coronavirus / physiology
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Viral Proteins / chemistry
Substances
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Antiviral Agents
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Receptors, Coronavirus
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Receptors, Virus
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Viral Proteins
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2