SARS-CoV-2: characteristics and current advances in research

Virol J. 2020 Jul 29;17(1):117. doi: 10.1186/s12985-020-01369-z.

Abstract

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamily Coronavirinae in the family Coronaviridae of the order Nidovirales and they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology characteristics and pathological characteristics are also different. We present a comprehensive survey of the latest coronavirus-SARS-CoV-2-from investigating its origin and evolution alongside SARS-CoV. Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review.

Keywords: COVID-19; Cardiovascular disease; Cytokine storm; Myocardial injury; SARS-CoV-2; Treatment; Venous thromboembolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Antiviral Agents / therapeutic use
  • Asymptomatic Infections
  • Betacoronavirus* / chemistry
  • Betacoronavirus* / classification
  • Betacoronavirus* / pathogenicity
  • Betacoronavirus* / physiology
  • COVID-19
  • COVID-19 Drug Treatment
  • COVID-19 Serotherapy
  • Comorbidity
  • Coronavirus Infections* / drug therapy
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / immunology
  • Coronavirus Infections* / pathology
  • Coronavirus Infections* / therapy
  • Disease Susceptibility
  • Evolution, Molecular
  • Genome, Viral
  • Humans
  • Immunization, Passive
  • Pandemics*
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / immunology
  • Pneumonia, Viral* / pathology
  • Pneumonia, Viral* / therapy
  • Receptors, Coronavirus
  • Receptors, Virus / metabolism
  • SARS-CoV-2
  • Severe acute respiratory syndrome-related coronavirus / chemistry
  • Severe acute respiratory syndrome-related coronavirus / classification
  • Severe acute respiratory syndrome-related coronavirus / pathogenicity
  • Severe acute respiratory syndrome-related coronavirus / physiology
  • Viral Proteins / chemistry

Substances

  • Antiviral Agents
  • Receptors, Coronavirus
  • Receptors, Virus
  • Viral Proteins
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2