Neuromodulation Therapy in Heart Failure: Combined Use of Drugs and Devices

Christopher O Sobowale; Yuichi Hori; Olujimi A Ajijola

doi:10.19102/icrm.2020.110705

Neuromodulation Therapy in Heart Failure: Combined Use of Drugs and Devices

J Innov Card Rhythm Manag. 2020 Jul 15;11(7):4151-4159. doi: 10.19102/icrm.2020.110705. eCollection 2020 Jul.

Authors

Christopher O Sobowale¹, Yuichi Hori^{1

2}, Olujimi A Ajijola¹

Affiliations

¹ UCLA Cardiac Arrhythmia Center, UCLA Neurocardiology Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
² Department of Cardiology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.

Abstract

Heart failure (HF) is the fastest-growing cardiovascular disease globally. The autonomic nervous system plays an important role in the regulation and homeostasis of cardiac function but, once there is HF, it takes on a detrimental role in cardiac function that makes it a rational target. In this review, we cover the remodeling of the autonomic nervous system in HF and the latest treatments available targeting it.

Keywords: Autonomic nervous system; heart failure; neuromodulation.