Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

Theranostics. 2020 Jul 9;10(18):8315-8342. doi: 10.7150/thno.45922. eCollection 2020.

Abstract

Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. Hitherto, SIRT3 has been substantiated to be involved in almost all aspects of mitochondrial metabolism and homeostasis, protecting mitochondria from a variety of damage. Accumulating evidence has recently documented that SIRT3 is associated with many types of human diseases, including age-related diseases, cancer, heart disease and metabolic diseases, indicating that SIRT3 can be a potential therapeutic target. Here we focus on summarizing the intricate mechanisms of SIRT3 in human diseases, and recent notable advances in the field of small-molecule activators or inhibitors targeting SIRT3 as well as their potential therapeutic applications for future drug discovery.

Keywords: Age-related disease; Cancer; Mitochondrial homeostasis; SIRT3; SIRT3 activator; SIRT3 inhibitor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation / drug effects
  • Aging / drug effects
  • Aging / metabolism
  • Drug Discovery*
  • Heart Diseases / drug therapy
  • Heart Diseases / metabolism
  • Humans
  • Metabolic Diseases / drug therapy
  • Metabolic Diseases / metabolism
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Molecular Targeted Therapy / methods
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • Sirtuin 3 / antagonists & inhibitors
  • Sirtuin 3 / metabolism*

Substances

  • SIRT3 protein, human
  • Sirtuin 3