Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies

Int J Mol Sci. 2020 Jul 25;21(15):5275. doi: 10.3390/ijms21155275.

Abstract

The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could precede FA, and that particular microbial community structures early in life could influence also the disease course. The identification of gut microbiome features in pediatric FA patients is driving new prevention and treatment approaches. This review is focused on the potential role of the gut microbiome as a target for FA prevention and treatment.

Keywords: dysbiosis; food allergy; gut microbiome.

Publication types

  • Review

MeSH terms

  • Child
  • Dysbiosis* / immunology
  • Dysbiosis* / therapy
  • Food Hypersensitivity* / immunology
  • Food Hypersensitivity* / microbiology
  • Food Hypersensitivity* / therapy
  • Gastrointestinal Microbiome / immunology*
  • Humans