Phenotypic and genotypic analysis of KPC-51 and KPC-52, two novel KPC-2 variants conferring resistance to ceftazidime/avibactam in the KPC-producing Klebsiella pneumoniae ST11 clone background

Lingxiao Sun; Wenhui Chen; Haibo Li; Lifeng Li; Xiaohui Zou; Jiankang Zhao; Binghuai Lu; Binbin Li; Chunlei Wang; Hui Li; Yingmei Liu; Bin Cao

doi:10.1093/jac/dkaa241

Phenotypic and genotypic analysis of KPC-51 and KPC-52, two novel KPC-2 variants conferring resistance to ceftazidime/avibactam in the KPC-producing Klebsiella pneumoniae ST11 clone background

J Antimicrob Chemother. 2020 Oct 1;75(10):3072-3074. doi: 10.1093/jac/dkaa241.

Authors

Lingxiao Sun^{1

2

3

4

5}, Wenhui Chen^{2

4

6}, Haibo Li^{2

3

4

5}, Lifeng Li⁷, Xiaohui Zou^{2

3

4

5}, Jiankang Zhao^{2

3

4

5}, Binghuai Lu^{2

3

4

5}, Binbin Li^{2

3

4

5}, Chunlei Wang^{2

3

4

5}, Hui Li^{2

3

4

5}, Yingmei Liu^{2

3

4

5}, Bin Cao^{1

2

3

4

5}

Affiliations

¹ China-Japan Friendship Hospital, National Clinical Research Centre for Respiratory Diseases, Capital Medical University, Beijing, China.
² Department of Pulmonary and Critical Care Medicine, Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
³ Laboratory of Clinical Microbiology and Infectious Diseases, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China.
⁴ Institute of Respiratory Medicine, Chinese Academy of Medical Science, National Clinical Research Centre of Respiratory Diseases, Beijing, China.
⁵ Tsinghua University-Peking University Joint Centre for Life Sciences, Beijing, China.
⁶ Department of Lung Transplantation, Centre for Lung Transplantation, Centre for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
⁷ Beijing GensKey Technology Co., Ltd, Beijing, China.

PMID: 32719857
DOI: 10.1093/jac/dkaa241

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Azabicyclo Compounds / pharmacology
Bacterial Proteins / genetics
Ceftazidime* / pharmacology
Clone Cells
Drug Combinations
Humans
Klebsiella Infections* / drug therapy
Klebsiella pneumoniae / genetics
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Azabicyclo Compounds
Bacterial Proteins
Drug Combinations
avibactam
Ceftazidime
beta-Lactamases