Abstract
Coronavirus disease 2019 (COVID-19) has attracted worldwide attention due to its speed of progression and elevated mortality rate. Amid the rush to develop treatments, recent hopes have focused on the anti-malarial drug chloroquine or the derivative hydroxychloroquine. Here, we briefly discuss the evidence for the potential use of these drugs with regard to the current pandemic.
Keywords:
COVID-19; Chloroquine; SARS-CoV-2; autophagy; clinical trial; hydroxychloroquine.
MeSH terms
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Autophagy / drug effects
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COVID-19 / epidemiology
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COVID-19 / pathology
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COVID-19 Drug Treatment*
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Cardiovascular Diseases / chemically induced
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Cardiovascular Diseases / epidemiology
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China / epidemiology
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Chloroquine / adverse effects*
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Chloroquine / analogs & derivatives
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Chloroquine / pharmacology
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Chloroquine / therapeutic use*
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Clinical Trials as Topic / statistics & numerical data
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Drug-Related Side Effects and Adverse Reactions / epidemiology
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Drug-Related Side Effects and Adverse Reactions / etiology
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France / epidemiology
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Humans
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Hydroxychloroquine / adverse effects
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Hydroxychloroquine / pharmacology
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Hydroxychloroquine / therapeutic use
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Italy / epidemiology
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Pandemics
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SARS-CoV-2 / drug effects*
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SARS-CoV-2 / physiology
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Severity of Illness Index
Substances
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Hydroxychloroquine
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Chloroquine