Non-coding RNAs in gastric cancer

Shanshan Xie; Yongxia Chang; Hao Jin; Feng Yang; Yanjun Xu; Xiaoyi Yan; Aifu Lin; Qiang Shu; Tianhua Zhou

doi:10.1016/j.canlet.2020.06.022

Non-coding RNAs in gastric cancer

Cancer Lett. 2020 Nov 28:493:55-70. doi: 10.1016/j.canlet.2020.06.022. Epub 2020 Jul 23.

Authors

Shanshan Xie¹, Yongxia Chang², Hao Jin², Feng Yang², Yanjun Xu³, Xiaoyi Yan⁴, Aifu Lin⁵, Qiang Shu⁶, Tianhua Zhou⁷

Affiliations

¹ The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China; Department of Cell Biology and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
² Department of Cell Biology and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China; Cancer Center, Zhejiang University, Hangzhou, 310058, China.
³ Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, 310022, China.
⁴ Cancer Center, Zhejiang University, Hangzhou, 310058, China.
⁵ MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: linaifu@zju.edu.cn.
⁶ The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China. Electronic address: shuqiangu@zju.edu.cn.
⁷ Department of Cell Biology and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China; Cancer Center, Zhejiang University, Hangzhou, 310058, China; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: tzhou@zju.edu.cn.

PMID: 32712234
DOI: 10.1016/j.canlet.2020.06.022

Abstract

Non-coding RNAs (ncRNAs) are functional RNA molecules that play crucial regulatory roles in many fundamental biological processes. The dysregulation of ncRNAs is significantly associated with the progression of human cancers, including gastric cancer. In this review, we have summarized the oncogenic or tumor-suppressive roles and the regulatory mechanisms of lncRNAs, miRNAs, circRNAs and piRNAs, and have discussed their potential as biomarkers or therapeutic targets in gastric cancer.

Keywords: Stomach cancer; circRNA; lncRNA; miRNA; piRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / genetics*
Disease Progression
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
RNA, Untranslated / genetics*
Stomach Neoplasms / genetics*

Substances

Biomarkers, Tumor
RNA, Untranslated