Abstract
Brain disorders are at the leading edge of global disease burden worldwide. Effective therapies are lagging behind because most drugs cannot reach their targets in the brain because of the blood-brain barrier (BBB). The new development of a BBB transport vehicle may bring us a step closer to solve this problem.
Copyright © 2020 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal / immunology
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Blood-Brain Barrier / drug effects
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Blood-Brain Barrier / metabolism*
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Brain Diseases / metabolism
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Brain Diseases / pathology*
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Drug Carriers / chemistry
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Humans
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Immunoconjugates / chemistry
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Immunoconjugates / immunology
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Immunoconjugates / pharmacology
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Receptors, Transferrin / immunology
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Receptors, Transferrin / metabolism
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Transcytosis
Substances
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Antibodies, Monoclonal
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Drug Carriers
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Immunoconjugates
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Receptors, Transferrin