Therapeutic TVs for Crossing Barriers in the Brain

Cell. 2020 Jul 23;182(2):267-269. doi: 10.1016/j.cell.2020.06.041.

Abstract

Brain disorders are at the leading edge of global disease burden worldwide. Effective therapies are lagging behind because most drugs cannot reach their targets in the brain because of the blood-brain barrier (BBB). The new development of a BBB transport vehicle may bring us a step closer to solve this problem.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / immunology
  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / metabolism*
  • Brain Diseases / metabolism
  • Brain Diseases / pathology*
  • Drug Carriers / chemistry
  • Humans
  • Immunoconjugates / chemistry
  • Immunoconjugates / immunology
  • Immunoconjugates / pharmacology
  • Receptors, Transferrin / immunology
  • Receptors, Transferrin / metabolism
  • Transcytosis

Substances

  • Antibodies, Monoclonal
  • Drug Carriers
  • Immunoconjugates
  • Receptors, Transferrin