Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Lipid Metabolism and Cardiovascular Diseases

Adv Exp Med Biol. 2020:1276:27-35. doi: 10.1007/978-981-15-6082-8_3.

Abstract

Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are the main members of BPI-like family based on the similar protein structure and conserved gene homology. Both LBP and BPI participate in lipid metabolism and thereby involve in pathogenesis of certain cardiovascular diseases. This chapter describes four aspects: (1) the loci of BPI and LBP in genome, (2) the characteristics of the cDNAs and expression patterns of LBP and BPI, (3) the structures and functions of LBP and BPI, and (4) the LBP and BPI in lipid metabolism and cardiovascular research.

Keywords: Bactericidal/permeability-increasing protein; Cardiovascular diseases; Cholesteryl ester transfer protein; Lipopolysaccharide-binding protein; Phospholipid transfer protein.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins*
  • Antimicrobial Cationic Peptides*
  • Blood Proteins*
  • Cardiovascular Diseases*
  • Carrier Proteins*
  • Humans
  • Lipid Metabolism*
  • Membrane Glycoproteins*
  • Permeability

Substances

  • Acute-Phase Proteins
  • Antimicrobial Cationic Peptides
  • Blood Proteins
  • Carrier Proteins
  • Membrane Glycoproteins
  • bactericidal permeability increasing protein
  • lipopolysaccharide-binding protein