Introduction: Lipomas are rarely found in primary mesenchymal tumors of the hypopharynx and larynx. When they do appear, they often macroscopically resemble a retention cyst or laryngeal nodule. The laryngeal spindle cell lipoma, a variant, is extremely rare.
Patient concerns: A 65-year-old woman presented with a 3-month history of pharyngeal paraesthesia. Laryngoscopy revealed the presence of a well-encapsulated, smooth-surfaced, yellowish, pedicled mass on the left epiglottis. Magnetic resonance imaging confirmed the epiglottic mass.
Diagnosis: Following excision of the mass, the diagnosis of an spindle cell lipoma was established and confirmed by immunohistochemistry.
Interventions: Surgical excision of the lesion using a controlled-temperature plasma technique (coblation).
Outcomes: At the last (4-year) follow-up evaluation, the patient was asymptomatic and without recurrence.
Conclusion: SLC involvement of the epiglottis is rare. Coblation is an effective means to remove it.