Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19

Respir Res. 2020 Jul 22;21(1):194. doi: 10.1186/s12931-020-01455-4.

Abstract

Rationale: Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.

Methods: Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19.

Results: A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56-2.13).

Conclusions: The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.

Keywords: COVID-19; Joint model; Prognostic marker; SpO2/FiO2.

Publication types

  • Letter

MeSH terms

  • Biomarkers / blood
  • COVID-19
  • China
  • Cohort Studies
  • Coronavirus Infections / blood*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / mortality*
  • Critical Care / methods*
  • Critical Illness / mortality*
  • Critical Illness / therapy
  • Female
  • Hospital Mortality / trends*
  • Humans
  • Intensive Care Units
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oximetry / methods
  • Oxygen / blood
  • Oxygen Consumption / physiology*
  • Pandemics
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / mortality*
  • Predictive Value of Tests
  • Prognosis

Substances

  • Biomarkers
  • Oxygen