Black phosphorus-based 2D materials for bone therapy

Liang Cheng; Zhengwei Cai; Jingwen Zhao; Fei Wang; Min Lu; Lianfu Deng; Wenguo Cui

doi:10.1016/j.bioactmat.2020.06.007

Black phosphorus-based 2D materials for bone therapy

Bioact Mater. 2020 Jul 10;5(4):1026-1043. doi: 10.1016/j.bioactmat.2020.06.007. eCollection 2020 Dec.

Authors

Liang Cheng¹, Zhengwei Cai^{1

2}, Jingwen Zhao¹, Fei Wang¹, Min Lu¹, Lianfu Deng¹, Wenguo Cui^{1

2}

Affiliations

¹ Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China.
² Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, Jiaxing 314000, PR China.

Abstract

Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

Keywords: Black phosphorus; Bone therapy; Nanomaterial; Tissue engineering.