The gastroprotective effect of the foxtail millet and adlay processing product against stress-induced gastric mucosal lesions in rats

Hui-Ching Lin; Shi-Yuan Sheu; Lee-Yan Sheen; Pei-Wen Sheu; Wenchang Chiang; Tzong-Fu Kuo

doi:10.1016/j.jtcme.2020.01.003

The gastroprotective effect of the foxtail millet and adlay processing product against stress-induced gastric mucosal lesions in rats

J Tradit Complement Med. 2020 Jan 17;10(4):336-344. doi: 10.1016/j.jtcme.2020.01.003. eCollection 2020 Jul.

Authors

Hui-Ching Lin¹, Shi-Yuan Sheu^{2

3}, Lee-Yan Sheen¹, Pei-Wen Sheu⁴, Wenchang Chiang¹, Tzong-Fu Kuo⁵

Affiliations

¹ Institute of Food Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan, ROC.
² School of Medicine, Chung Shan Medical University, No.110, Sec.1, Jianguo N. Rd., Taichung, 40201, Taiwan, ROC.
³ Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N. Rd., Taichung, 40201, Taiwan, ROC.
⁴ Taipei First Girls' High School, No.165, Sec. 1, Chongqing S. Rd., Taipei, 10045, Taiwan, ROC.
⁵ Department of Post-Baccalaureate Veterinary Medicine, Asia University, No. 500, Lioufeng Rd., Wufeng, Taichung, 41354, Taiwan, ROC.

Abstract

Foxtail millet (Setaria italica (L.) P. Beauv.) and adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) seeds have substantial benefits possesses remarkable edible and nutritive values, and ease of processing and food manufacturing. They have nutraceutical properties in the form of antioxidants which prevent deterioration of human health and have long been used in traditional Chinese medicine as a remedy for many diseases. The present study is designed to investigate the gastroprotective effect of foxtail millet and adlay processing product (APP) diet on water immersion restraint stress (WIRS) induced ulceration in rats. We examined the effects of intake of AIN-93G diet containing either foxtail millet (10, 20 and 40%, 4 weeks) or APP (15 and 30%, 5 weeks) on macroscopic ulcer index (UI), plasma calcium level, lipid peroxidation products (estimated by the thiobarbituric acid reactive substances; TBARS), non-protein sulfhydryl (NPSH), digestive enzyme activities, and histopathology were determined. The results showed that pretreatment with millet and adlay diets significantly prevented the gastric mucosal lesion development. In addition, ulcerated rats showed depletion of NPSH levels whereas treatment with millet and adlay reverted this decline in stress-induced rats. Histological studies confirmed the results. The finding suggests that millet and adlay diets promote ulcer protection by the decrease in ulcer index, TBARS values and increase NPSH concentrations. Millet and adlay diets retain the advantage of being a natural product which may protect the gastric mucosa against ulceration.

Keywords: Adlay; Foxtail millet; Gastroprotective effect; Peptic ulcer disease; Water immersion restraint stress.