Sinonasal undifferentiated carcinoma: Institutional trend toward induction chemotherapy followed by definitive chemoradiation

Nyall R London Jr; Ahmed Mohyeldin; Georges Daoud; Mauricio E Gamez; Dukagjin Blakaj; Marcelo Bonomi; Daniel M Prevedello; Ricardo L Carrau

doi:10.1002/hed.26357

Sinonasal undifferentiated carcinoma: Institutional trend toward induction chemotherapy followed by definitive chemoradiation

Head Neck. 2020 Nov;42(11):3197-3205. doi: 10.1002/hed.26357. Epub 2020 Jul 18.

Authors

Nyall R London Jr^{1

2

3}, Ahmed Mohyeldin^{4

5}, Georges Daoud¹, Mauricio E Gamez⁶, Dukagjin Blakaj⁶, Marcelo Bonomi⁷, Daniel M Prevedello⁴, Ricardo L Carrau^{1

4}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
² Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
³ Sinonasal and Skull Base Tumor Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA.
⁴ Department of Neurosurgery, The Ohio State University, Columbus, Ohio, USA.
⁵ Department of Neurosurgery, Stanford University, Palo Alto, California, USA.
⁶ Department of Radiation Oncology, The Ohio State University, Columbus, Ohio, USA.
⁷ Department of Medical Oncology, The Ohio State University, Columbus, Ohio, USA.

PMID: 32681692
DOI: 10.1002/hed.26357

Abstract

Background: Recent reports have investigated the nascent role of induction chemotherapy for sinonasal undifferentiated carcinoma (SNUC). The goal of this study was to ascertain trends in treatment pattern changes for SNUC at a single institution and design a treatment algorithm utilized at our institution.

Methods: Retrospective chart analysis of 21 cases of SNUC from 2010 to 2018.

Results: Of 21 patients in this cohort, 18 (85.7%) presented with T4 disease, 7 (33.3%) presented with nodal disease, and 3 (14.3%) presented with distant metastasis. Since 2016, patients have been managed by induction chemotherapy followed by concurrent chemoradiation. To this point, patients treated with TPF induction chemotherapy followed by concurrent chemoradiation show no evidence of disease; however, the average follow up time is 16.8 months.

Conclusions: The multimodality treatment for SNUC continues to evolve, as highlighted by this study, toward increased use of induction chemotherapy followed by chemoradiotherapy.

Keywords: definitive chemoradiation; induction chemotherapy; sinonasal undifferentiated carcinoma.

MeSH terms

Carcinoma
Chemoradiotherapy
Humans
Induction Chemotherapy*
Maxillary Sinus Neoplasms* / therapy
Retrospective Studies

Supplementary concepts

Sinonasal undifferentiated carcinoma