The importance of BDNF and RAGE in diabetes-induced dementia

Oh Yoen Kim; Juhyun Song

doi:10.1016/j.phrs.2020.105083

The importance of BDNF and RAGE in diabetes-induced dementia

Pharmacol Res. 2020 Oct:160:105083. doi: 10.1016/j.phrs.2020.105083. Epub 2020 Jul 15.

Authors

Oh Yoen Kim¹, Juhyun Song²

Affiliations

¹ The Department of Food Science and Nutrition, Dong-A University, Busan 49315, Republic of Korea; The Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan 49315, Republic of Korea. Electronic address: oykim@dau.ac.kr.
² The Department of Anatomy, Chonnam National University, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of Korea. Electronic address: juhyunsong@chonnam.ac.kr.

PMID: 32679182
DOI: 10.1016/j.phrs.2020.105083

Abstract

Diabetes-induced dementia is an emerging neurodisorder all over the world. The prevalence rates of dementia and diabetes have been gradually increasing worldwide. Diabetes has been known to lead to oxidative stress, inflammation aggravation, and hyperglycemia conditions in the brain. Various diabetic implications cause the lower secretion of brain-derived neurotrophic factor (BDNF) and the increase of receptor for advanced glycation end products (RAGE), ultimately leading to both cerebrovascular dysfunction and cognitive decline. Here, we summarized the significant evidences highlighting the specific mechanisms between BDNF and RAGE and cerebrovascular dysfunction and memory function and how these relate to diabetes-induced dementia. Especially, we review that the association between BDFN and RAGE in neuroinflammation, the reduction of long-term potentiation, and the vascular implications in brain.

Keywords: Brain-derived neurotrophic factor (BDNF); Cerebrovascular dysfunction; Cognitive decline; Diabetes-induced dementia; Receptor for advanced glycation end products (RAGE).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Blood Glucose / metabolism
Brain / blood supply*
Brain-Derived Neurotrophic Factor / metabolism*
Cerebral Arteries / metabolism*
Cerebral Arteries / physiopathology
Cerebrovascular Circulation
Cognition*
Dementia, Vascular / epidemiology
Dementia, Vascular / metabolism*
Dementia, Vascular / physiopathology
Dementia, Vascular / psychology
Diabetes Complications / epidemiology
Diabetes Complications / metabolism*
Diabetes Complications / physiopathology
Diabetes Complications / psychology
Glycation End Products, Advanced / metabolism
Humans
Long-Term Potentiation
Memory
Receptor for Advanced Glycation End Products / metabolism*
Risk Factors
Signal Transduction

Substances

Blood Glucose
Brain-Derived Neurotrophic Factor
Glycation End Products, Advanced
Receptor for Advanced Glycation End Products