Light-induced liposomes for cancer therapeutics

Prog Lipid Res. 2020 Jul:79:101052. doi: 10.1016/j.plipres.2020.101052. Epub 2020 Jul 15.

Abstract

The emerging nanomedicine therapeutics have incorporated photonics technologies to develop precise medical treatment. Among the light regulated approaches, light-induced liposome technology has been explored and developed as a novel tool for spatiotemporal control of cargo release. Compared with the traditional liposome formulation, this triggering feature largely enhanced the therapeutic efficacy and minimized the side effects of the therapeutic substance. In this review paper, we discussed the basics of the light-induced liposomes including the engineering methods and photoresponsiveness mechanisms. We also reviewed current biomedical studies relating to light-induced liposome delivery systems, with an emphasis in the field of cancer therapy.

Keywords: Cancer therapeutics; Drug/gene delivery; Light triggering; Liposomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use*
  • Drug Delivery Systems
  • Humans
  • Light*
  • Liposomes / chemistry
  • Liposomes / radiation effects*
  • Nanomedicine
  • Neoplasms / drug therapy*
  • Precision Medicine

Substances

  • Antineoplastic Agents
  • Liposomes