Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects

Eur Respir J. 2020 Aug 20;56(2):2002378. doi: 10.1183/13993003.02378-2020. Print 2020 Aug.

Abstract

This study demonstrates increased protein levels of ACE2 in alveolar and bronchial epithelium of smokers and subjects with COPD, which might facilitate host cell entry of SARS-CoV-2 https://bit.ly/2ZazOrd

Publication types

  • Letter

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Belgium
  • Betacoronavirus / metabolism*
  • Biomarkers / blood
  • Biopsy, Needle
  • Cross-Sectional Studies
  • Female
  • Humans
  • Immunohistochemistry
  • In Vitro Techniques
  • Linear Models
  • Male
  • Multivariate Analysis
  • Peptidyl-Dipeptidase A / metabolism*
  • Pulmonary Disease, Chronic Obstructive / blood
  • Pulmonary Disease, Chronic Obstructive / epidemiology
  • Pulmonary Disease, Chronic Obstructive / pathology*
  • RNA, Messenger / blood*
  • Real-Time Polymerase Chain Reaction / methods
  • Respiratory Mucosa / metabolism
  • Respiratory Mucosa / pathology*
  • SARS-CoV-2
  • Sensitivity and Specificity
  • Smoking / blood
  • Smoking / epidemiology*
  • Specimen Handling
  • Statistics, Nonparametric

Substances

  • Biomarkers
  • RNA, Messenger
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2