Decumbic anhydride from the stem barks of Swintonia floribunda (Anacardiaceae)

Z Naturforsch C J Biosci. 2020 Jul 16;76(1-2):49-53. doi: 10.1515/znc-2020-0136. Print 2021 Jan 27.

Abstract

From an EtOAc-soluble fraction of the stem barks of Swintonia floribunda (Anacardiaceae), decumbic anhydride (1) and four known compounds 2-5 were isolated. Their chemical structures were elucidated based on the spectroscopic data interpretation. The GIAO-DFT calculation of 13C NMR chemical shifts was carried out to clarify the structure of 1. The absolute configuration of 1 was assigned based on the Cotton effects in its ECD spectrum. Compound 1 showed potent tyrosinase inhibitory activity with an IC50 value of 52.2 μM.

Keywords: Anacardiaceae; Swintonia floribunda; decumbic anhydride; tyrosinase inhibitory.

MeSH terms

  • Anacardiaceae / chemistry*
  • Anhydrides / chemistry
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Lactones / chemistry
  • Monophenol Monooxygenase / antagonists & inhibitors
  • Phytochemicals / chemistry*
  • Phytochemicals / pharmacology
  • Plant Bark / chemistry

Substances

  • Anhydrides
  • Enzyme Inhibitors
  • Lactones
  • Phytochemicals
  • Monophenol Monooxygenase