SARS-CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19

J Matern Fetal Neonatal Med. 2022 Aug;35(15):2876-2878. doi: 10.1080/14767058.2020.1793318. Epub 2020 Jul 16.

Abstract

Background: Data concerning the presence of SARS-CoV-2 in the female genital system is scarce; however, this information is important for understanding whether the virus can transmit sexually or from mother to child. The aim of this study was to investigate whether pregnant women with COVID-19 have virus in their lower genital tract.

Methods: In this cross-sectional study, we present an analysis of prospectively gathered data collected at a single tertiary university hospital from 19 April to 19 May 2020. We included 13 pregnant women hospitalized with suspected COVID-19. Results of laboratory tests, imaging tests, and nucleic acid tests on vaginal swabs for SARS-CoV-2 were also analyzed for pregnant women with a clinical diagnosis of COVID-19.

Results: Twelve pregnant women with confirmed COVID-19 were included in this study. Mean age was 32 ± 7.9 years. All patients had mild symptoms and were followed in the maternity ward, with none of them needing critical care unit follow-up. All lower genital tract samples were negative for SARS-CoV-2.

Conclusion: We demonstrated that SARS-CoV-2 was not present in the vaginal fluid of pregnant women. This finding may indicate that the female genital tract is not a route of SARS-CoV-2 transmission.

Keywords: COVID-19 and vaginal delivery; SARS-CoV-2; pregnant women; vaginal fluid.

MeSH terms

  • Adult
  • COVID-19*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Infectious Disease Transmission, Vertical
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnant Women
  • SARS-CoV-2
  • Young Adult