New Copper(I) Complex with a Coumarin as Ligand with Antibacterial Activity against Flavobacterium psychrophilum

Molecules. 2020 Jul 13;25(14):3183. doi: 10.3390/molecules25143183.

Abstract

A new copper (I) complex, [Cu(NN1)2](ClO4), was synthesized, where NN1 was a imine ligand 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one obtained by a derivatization of natural compound coumarin. The structural characterization in solution was done by NMR techniques, UV-Vis and cyclic voltammetry. The potential antibacterial effect of [Cu(NN1)2](ClO4), was assessed for F. psychrophilum isolated 10094. F. psychrophilum is a Gram-negative bacterium which causes diseases such as bacterial cold-water disease and rainbow trout fry syndrome, causing large economic losses in the freshwater salmonid aquaculture industry. This complex show to have antibacterial activity against F. psychrophilum 10094 at non-cytotoxic concentration in cell line derived from trout (F. psychrophilum 10094 IC50 16.0 ± 0.9; RT-GUT IC50 53.0 ± 3.1 µg/mL).

Keywords: F. psychrophilum; antibacterial activity; coordination compounds; copper (I); coumarin.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Cell Line
  • Copper / pharmacology*
  • Coumarins / pharmacology*
  • Fish Diseases / microbiology*
  • Flavobacterium / drug effects*
  • Oncorhynchus mykiss
  • Salmon

Substances

  • Anti-Bacterial Agents
  • Coumarins
  • Copper

Supplementary concepts

  • Flavobacterium psychrophilum